Additional Resources

Human Health Science

Buekers J, De Brouwere K, Lefebvre W, Willems H, Vandenbroele M, Van Sprang P, Eliat-Eliat M, Hicks K, Schlekat CE, Oller AR, 2015. Assessment of human exposure to environmental sources of nickel in Europe: Inhalation exposure. Science of the Total Environment 521-522: 359-371.

Buxton S, Garman E, Heim KE, Lyons-Darden T, Schlekat CE, Taylor MD, Oller AR, 2019. Concise review of nickel human health toxicology and ecotoxicology. Inorganics 7(7): 89.

Efremenko A, Campbell Jr JL, Dodd DE, Oller AR, Clewell HK , 2017. Time- and concentration-dependent genomic responses of the rat airway to inhaled nickel sulfate. Environ Mol Mutagen, doi: 10.1002/em.22139.

Efremenko A, Campbell Jr JL, Dodd DE, Oller AR, Clewell HK, 2014. Time- and concentration-dependent genomic responses of the rat airway to inhaled nickel subsulfide. Toxicol Appl Pharmacol 279(3): 441-454.

Gray DL, Wallace LA, Brinkman MC, Buehler SS, La Londe C, 2014. Respiratory and Cardiovascular Effects of Metals in Ambient Particulate Matter: A Critical Review. Book_329441_RECT_ Volume 234, Chapter 3, Reviews of Environmental Contamination and Toxicology, doi: 10.1007/978-3-319-10638-0_3.

Haber LT, Bates HK, Allen BC, Vincent MJ, Oller AR, 2017. Derivation of an oral toxicity reference value for nickel. Regul Toxicol Pharmacol 87(Suppl 1) S1-S18. doi: 10.1016/j.yrtph.2017.03.011. Epub 2017 Mar 12.

Heim K, Basketter D, 2018. Chapter 5. Metal Exposure Regulations and Their Effect on Allergy Prevention. In Metal Allergy: From Dermatitis to Implant and Device Failure. Editors: Chen JK and Thyssen JP. Springer International Publishing. pp. 39-54.

Heim KE, Danzeisen R, Verougstraete V, Gaidou F, Brouwers T, Oller AR, 2020. Bioaccessibility of nickel and cobalt in synthetic gastric and lung fluids and its potential use in alloy classification. Regul Toxicol Pharmacol 110: 104549.

Henderson RG, Verougstraete V, Anderson K, Arbildua JJ, Thomas O Brock, Brouwers T, Cappellini D, Delbeke K, Herting G, Hixon G, Odnevall Wallinder I, Rodriquez PH, Van Assche F, Wilrich P, Oller AR, 2014. Inter-laboratory Validation of Bioaccessibility Testing for Metals. Regul Toxicol and Pharmacol 70(1): 170-181.

Lombaert N, Mackie C, Verougstraete V, Brouwers T, Van Assche F, Oller A, 2018. Use of bioelution as a screening tool for characterization of substances. Am J Analytical Chemistry 9: 134-149.

Nickel Institute, 2016. Workshop on Nickel Dermatitis. Chicago, Illinois, June 2016. Meeting report. pp 2. 

Nixon RL, Higgins CL, Maor D, Rajgopal BH, Lalji A, Heim KE, 2018. Does clinical testing support the current guidance definition of prolonged contact for nickel allergy? Contact Dermatitis 79(6): 356-364.

Oller AR, Oberdörster G, 2016. Incorporation of dosimetry in the derivation of reference concentrations for ambient or workplace air: a conceptual approach. J Aerosol Science 99: 40-45.

Oller AR, Oberdörster G, Seilkop S, 2014. Derivation of PM10 size-selected human equivalent concentrations of inhaled nickel based on cancer and non-cancer effects in the respiratory tract. Inhal Toxicol 26(9): 559-578.

Verougstraete V, Danzeisen R, Bruzlaff A, Oller A, Heim K, Vetter D, Müller C, Battersby RV, Oorts K, Lison D, 2017. Mechanisms underlying toxicity of complex inorganic materials. Book Chapter. Risk Management of Complex Inorganic Materials. A practical guide. Edited by V. Verougstraete. Elsevier Inc.

Verougstraete V, Henderson R, Mackie C, Newson T, Oller A, 2017. Human health (toxicity) assessment of complex inorganic materials. Book Chapter. Risk Management of Complex Inorganic Materials. A practical guide. Edited by V. Verougstraete. Elsevier Inc.

Warshaw EM, Aschenbeck KA, DeKoven JG, Maibach HI, Taylor JS, Sasseville D, Belsito DV, Fowler JF Jr, Zug KA, Zirwas MJ, Fransway AF, DeLeo VA, Marks JG Jr, Pratt MD, Mathias T, 2018. Epidemiology of pediatric nickel sensitivity: Retrospective review of North American Contact Dermatitis Group (NACDG) data 1994-2014. J Am Acad Dermatol 79(4): 664-671.

Warshaw EM, Aschenbeck KA, DeKoven JG, Maibach HI, Taylor JS, Sasseville D, Belsito DV, Fowler JF Jr, Zug KA, Zirwas MJ, Fransway AF, DeLeo VA, Marks JG Jr, Pratt MD, Mathias T, 2017. Piercing and Metal Sensitivity: Extended Analysis of the North American Contact Dermatitis Group Data, 2007-2014. Dermatitis 28(6): 333-341.

Warshaw EM, Zhang AJ, DeKoven JG, Maibach HI, Belsito DV, Sasseville D, Fowler JF Jr, Fransway AF, Mathias T, Pratt MD, Marks JG Jr, Zug KA, Zirwas MJ, Taylor JS, DeLeo VA, 2019. Epidemiology of nickel sensitivity: Retrospective cross-sectional analysis of North American Contact Dermatitis Group data 1994-2014. J Am Acad Dermatol 80(3): 701-713.

 

Below are two separate reports to evaluate the potential effects of nickel sulfate hexahydrate when administered orally to rats over the course of one and two generations.

SLI (Springborn Laboratories Inc.), 2000a. A One-generation Reproduction Rangefinding Study in Rats with Nickel Sulfate Hexahydrate. Springborn Laboratories Inc., Spencerville. SLI Study No. 3472.3.

SLI (Springborn Laboratories Inc.), 2000b. An Oral (Gavage) Two-generation Reproduction Toxicity Study in Sprague-Dawley Rats with Nickel Sulfate Hexahydrate. Final Report. Springborn Laboratories Inc., Spencerville. SLI Study No. 3472.4.

Environmental Science

Adams W, Blust R, Dwyer R, Mount D, Nordheim E, Rodriguez PH, Spry D, 2020. Bioavailability Assessment of Metals in Freshwater Environments: A Historical Review. Environ Toxicol Chem 39: 48-59. doi: 10.1002/etc.4558.

Binet M, Adams M, Gissi F, Golding L, Schlekat C, Garman E, Merrington G, Stauber J, 2017. Toxicity of nickel to tropical freshwater and sediment biota–a critical literature review and gap analysis. Environmental Toxicology and Chemistry, doi: 10.1002/etc.3988.

Blewett TA, Glover CN, Fehsenfeld S, Lawrence MJ, Niyogi S, Goss GG, Wood CM, 2015. Making sense of nickel accumulation and sub-lethal toxic effects in saline waters: Fate and effects of nickel in the green crab, Carcinus maenas. Aquat Toxicol 164: 23-33.

Blewett TA, Wood CM, 2015. Low salinity enhances NI-mediated oxidative stress and sub-lethal toxicity to the green shore crab (Carcinus maenas). Ecotoxicol Environ Saf 122: 159-70.

Brix KV, DeForest DK, Tear L, Peijnenburg W, Peters A, Middleton ET, Erickson R, 2020. Development of Empirical Bioavailability Models for Metals. Environ Toxicol Chem 39: 85-100. doi: 10.1002/etc.4570.

Brix KV, Schlekat CE, Garman E, 2016. The mechanisms of nickel toxicity in aquatic environments: An Adverse Outcome Pathway (AOP) analysis. Environ Toxicol Chem, doi: 10.1002/etc.3706.

Brix KV, Tellis MS, Crémazy A, Wood CM, 2017. Characterization of the effects of binary metal mixtures on short-term uptake of Cd, Pb, and Zn by rainbow trout (Oncorhynchus mykiss). Aquat Toxicol 193: 217-227. doi: 10.1016/j.aquatox.2017.10.015.

Brix KV, Tellis MT, Crémazy A, Wood CM, 2016. Characterization of the effects of binary metal mixtures on short-term uptake of Ag, Cu, and Ni by rainbow trout (Oncorhynchus mykiss). Aquatic Toxicology 180: 236-246.

Burton GA Jr, Hudson ML, Huntsman P, Carbonaro RF, Rader KJ, Waeterschoot H, Baken S, Garman E, 2019. Weight‐of‐Evidence Approach for Assessing Removal of Metals from the Water Column for Chronic Environmental Hazard Classification. Environ Toxicol Chem 38: 1839-1849. doi: 10.1002/etc.4470.

Chandler GT, Schlekat CE, Garman E, He L, Washburn K, Stewart E, Ferry JL, 2014. Sediment Nickel Bioavailability and Toxicity to Estuarine Crustaceans of Contrasting Bioturbative Behaviors–An Evaluation of the SEM-AVS Paradigm. Environmental Science and Technology 48(21): 12893-901.

Costello DM, Hammerschmidt CR, Burton GA, 2016. Nickel partitioning and toxicity in sediment during aging: Variation in toxicity related to stability of metal partitioning. Environmental Science & Technology 50: 11337-11345.

Crémazy A, Brix KV, Wood CM, 2019. Using the Biotic Ligand Model framework to investigate binary metal interactions on the uptake of Ag, Cd, Cu, Ni, Pb and Zn in the freshwater snail Lymnaea stagnalis. Science of The Total Environment 647: 1611–1625. doi: 10.1016/j.scitotenv.2018.07.455.

Danner KM, Hammerschmidt CR, Costello DM, Burton GA, 2015. Copper and nickel partitioning with nanoscale goethite under variable aquatic conditions. Environ Toxicol Chem 34: 1705-1710.

Farley KJ, Meyer JS, 2015. Metal Mixture Modeling Evaluation: 3. Lessons learned and steps forward. Environmental Toxicology and Chemistry 34(4): 821-832. doi: 10.1002/etc.2837.

Garman ER, Meyer JS, Bergeron CM, Blewett TA, Clements WH, Elias MC, Farley KJ, Gissi F, Ryan AC, 2020. Validation of Bioavailability‐Based Toxicity Models for Metals. Environ Toxicol Chem 39: 101-117. doi: 10.1002/etc.4563.

Gissi F, Reichelt-Brushett AJ, Chariton AA, Stauber JL, Greenfield P, Humphrey C, Salmon M, Stephenson SA, Cresswell T, Jolley DF, 2019. The effect of dissolved nickel and copper on the adult coral Acropora muricata and its microbiome. Environmental Pollution 250: 792-806.

Gissi F, Stauber J, Reichelt-Brushett A, Harrison PL, Jolley DF, 2017. Inhibition in fertilisation of coral gametes following exposure to nickel and copper. Ecotoxicology and Environmental Safety 145: 32-41. doi:10.1016/j.ecoenv.2017.07.009.

Gissi F, Stauber JL, Binet MT, Golding LA, Adams MS, Schlekat C, Garman E, Jolley DF, 2016. A review of nickel toxicity to marine and estuarine tropical biota with particular reference to the South East Asian and Melanesian region. Environ Pollut 218: 1308-1323.

Gissi F, Stauber JL, Binet MT, Trenfield MA, Van Dam JW, Jolley DF, 2018. Assessing the chronic toxicity of nickel to a tropical marine gastropod and two crustaceans. Ecotoxicology and Environmental Safety 159: 284-292.

Hale B, Gopalapillai Y, Pellegrino A, Jennett T, Kikkert J, Lau W, Schlekat C, McLaughlin M, 2017. Validation of Site-Specific Soil Ni Toxicity Thresholds with Independent Ecotoxicity and Biogeochemistry Data for Elevated Soil Ni. Environmental Pollution 231: 165-172.

Hommen U, Knopf B, Rudel H, Schafers C, De Schamphelaere K, Schlekat C, Garman E, 2015. A microcosm study to support aquatic risk assessment of nickel: Community-level effects and comparison with bioavailability-normalized species sensitivity distributions. Environmental Toxicology and Chemistry, doi: 10.1002/etc.3255.

Huntsman P, Beaudoin R, Rader KJ, Carbonaro RF, Allen Burton G Jr, Hudson M, Baken S, Garman E, Waeterschoot H, 2019. Method Development for Determining the Removal of Metals from the Water Column under Transformation/Dissolution Conditions for Chronic Hazard Classification. Environ Toxicol Chem 38: 2032-2042. doi:10.1002/etc.4471.

Leonard EM, Banerjee U, D'Silva JJ, Wood CM, 2014. Chronic nickel bioaccumulation and sub-cellular fractionation in two freshwater teleosts, the round goby and the rainbow trout, exposed simultaneously to waterborne and dietborne nickel Aquat Toxicol 154C: 141-153.

Leonard EM, Marentette JR, Balshine S, Wood CM, 2014. Critical body residues, Michaelis-Menten analysis of bioaccumulation, lethality and behaviour as endpoints of waterborne Ni toxicity in two teleosts. Ecotoxicology 23: 147-162.

Martin OV, Adams J, Beasley A, Belanger S, Breton R, Brock T, Buonsante VA, Burgos MK, Green J, Guiney P, Hall T, Hanson ML, Harris MJ, Henry TA, Huggett D, Junghans M, Laskowski R, Maack G, Moermond C, Panter G, Pease A, Poulsen V, Roberts M, Rudén C, Schlekat C, Schoeters I, Solomon K, Staveley J, Stubblefield W, Sumpter J, Warne MSJ, Wentsel R, Wheeler J, Wolff BA, Yamazaki K, Zahner H, 2019. Improving environmental risk assessments of chemicals: steps towards evidence-based ecotoxicology. Environment International 128: 210-217.

Mebane CA, Chowdhury MJ, De Schamphelaere KA, Lofts S, Paquin PR, Santore RC, Wood CM, 2020. Metal Bioavailability Models: Current Status, Lessons Learned, Considerations for Regulatory Use, and the Path Forward. Environ Toxicol Chem 39: 60-84. doi: 10.1002/etc.4560.

Mendonca R, Daley J, Hudson M, Schlekat C, Burton, Jr. GA, Costello D, 2017. Metal Oxides in Surface Sediment Control Nickel Bioavailability to Benthic Macroinvertebrates Environ Sci Technol 51 (22): 13407-13416.

Merrington G, Peters A, Schlekat C, 2016. Accounting for metal bioavailability in assessing water quality: A step change? Environ Toxicol Chem 35: 257-265.

Meyer JS, Farley KJ, Balistrieri LS, De Schamphelaere KAC, Iwasaki Y, Janssen C, Kamo M, Lofts S, Mebane C, Naito W, Ryan AC, Santore R, Tipping E, 2015. Metal Mixture Modeling Evaluation Project: 2. Comparison of Four Modeling Approaches. Environmental Toxicology and Chemistry 34(4): 741-753. doi: 10.1002/etc.2820.

Meyer JS, Farley KJ, Garman ER, 2015. Metal Mixtures Modeling Evaluation: 1. Background. Environmental Toxicology and Chemistry 34(4): 726-740. doi: 10.1002/etc.2792.

Nys C, Asselman J, Hochmuth JD, Janssen CR, Blust R, Smolders E, De Schamphelaere KAC, 2015. Mixture toxicity of nickel and zinc to Daphnia magna is noninteractive at low effect sizes but becomes synergistic at high effect sizes: Interactive effects in a binary Ni-Zn mixture Environmental Toxicology and Chemistry 34(5) 1091-102.

Nys C, Janssen CR, Blust R, Smolders E, De Schamphelaere KA, 2016. Reproductive toxicity of binary and ternary mixture combinations of nickel, zinc, and lead to Ceriodaphnia dubia is best predicted with the independent action model. Environ Toxicol Chem 35(7): 1796-1805. doi: 10.1002/etc.3332.

Nys C, Janssen CR, Van Sprang P, De Schamphelaere KA, 2016. The effect of pH on chronic aquatic nickel toxicity is dependent on the pH itself: Extending the chronic nickel bioavailability models. Environ Toxicol Chem 35: 1097-1106.

Nys C, Van Regenmortel T, De Schamphelaere K, 2019. The Effects of Nickel on the Structure and Functioning of a Freshwater Plankton Community Under High Dissolved Organic Carbon Conditions: A Microcosm Experiment. Environ Toxicol Chem 38: 1923-1939. doi: 10.1002/etc.4504.

Nys C, Van Regentmortel T, De Schamphelaere K, 2018. The effects of nickel on the structure and functioning of a freshwater plankton community: a microcosm experiment. Environmental Toxicology and Chemistry [Accepted pending revisions].

Nys C, Van Regenmortel T, Janssen CR, Blust R, Smolders E, De Schamphelaere KA, 2016. Comparison of chronic mixture toxicity of nickel-zinc-copper and nickel-zinc-copper-cadmium mixtures between Ceriodaphnia dubia and Pseudokirchneriella subcapitata. Environ Toxicol Chem, doi: 10.1002/etc.3628.

Peters A, Merrington G, Leverett D, Wilson I, Schlekat C, Garman E, 2019. Comparison of the chronic toxicity of nickel to temperate and tropical freshwater species. Environ Toxicol Chem 38: 1211-1220. doi: 10.1002/etc.4384.

Peters A, Merrington G, Schlekat C, De Schamphelaere K, Stauber J, Batley G, Harford A, van Dam R, Pease C, Mooney T, Warne M, Hickey C, Glazebrook P, Chapman J, Smith R, Krassoi R, 2018. Validation of the nickel biotic ligand model for locally relevant species in Australian freshwaters. Environmental Toxicology and Chemistry 37(10): 2566-2574.

Peters A, Schlekat CE, Merrington G, 2016. Does the Scientific Underpinning of Regulatory Tools to Estimate Bioavailability of Nickel in Freshwaters Matter? The European-Wide Environmental Quality Standard for Nickel. Environ Toxicol Chem, doi: 10.1002/etc.3510.

Peters A, Simpson P, Merrington G, Schlekat C, Rogevich Garman E, 2014. Assessment of the effects of nickel on benthic macroinvertebrates in the field. Environmental Science and Pollution Research 21: 193-204.

Ruden C, Adams J, Agerstrand M, Brock TCM, Poulsen V, Schlekat CE, Wheeler JR, Henry TR, 2016. Assessing the relevance of ecotoxicological studies for regulatory decision-making. Integrated Environmental Assessment and Management, doi: 10.1002/ieam.1846.

Schlekat C, Stubblefield W, Gallagher K, 2020. State of the Science on Metal Bioavailability Modeling: Introduction to the Outcome of a Society of Environmental Toxicology and Chemistry Technical Workshop. Environ Toxicol Chem 39: 42-47. doi: 10.1002/etc.4561.

Schlekat CE, Garman ER, Vangheluwe MLU, Burton GA Jr, 2016. Development of a bioavailability-based risk assessment approach for Ni in sediments. Integrated Environmental Assessment and Management 12(4): 753-46. doi: 10.1002/ieam.1720.

Schlekat CE, Merrington G, Leverett D, Peters A, 2017. Chemical standard derivation for the protection of aquatic life: A guided world tour. Integrated Environmental Assessment and Management 13(4): 794-796. doi: 10.1002/ieam.1919.

Skeaff JM, Beaudoin R, 2015. Transformation/Dissolution Characteristics of a Nickel Matte and Nickel Concentrates for Acute and Chronic Hazard Classification. Integrated Environmental Assessment and Management 11(1): 130-42. doi:10.1002/ieam.1573.

Tellis MS, Lauer MM, Nadella SR, Bianchini A, Wood CM, 2014. The effects of Cu and Ni on the embryonic life stages of the purple sea urchin (Strogylocentrotus purpuratus). Archiv Environ Contam Toxicol, doi: 10.1007/s00244-014-0069-8.

Traudt EM, Ranville JF, Meyer JS, 2017. Effect of age on acute toxicity of cadmium, copper, nickel, and zinc in individual-metal exposures to Daphnia magna neonates. Environ Toxicol Chem 36: 113-119. doi: 10.1002/etc.3507.

Traudt EM, Ranville JF, Smith SA, Meyer JS, 2016. A test of the additivity of acute toxicity of binary-metal mixtures of Ni with Cd, Cu, and Zn to Daphnia magna, using the inflection point of the concentration–response curves. Environ Toxicol Chem 35: 1843-1851. doi: 10.1002/etc.3342.

Van Genderen E, Adams W, Dwyer R, Garman ER, Gorsuch J, 2015. Modeling and Interpreting Biological Effects of Mixtures in the Environment Introduction to the Metal Mixture Modeling Evaluation Project. Environmental Toxicology and Chemistry 34(4):721-5. doi: 10.1002/etc.2750.

Van Genderen E, Stauber JL, Delos C, Eignor D, Gensemer RW, McGeer J, Merrington G, Whitehouse P, 2020. Best Practices for Derivation and Application of Thresholds for Metals Using Bioavailability‐Based Approaches. Environ Toxicol Chem 39: 118-130. doi: 10.1002/etc.4559.

 

 

A Special Section of Environmental Toxicology and Chemistry on the Metal Mixture Modeling Evaluation Project was supported by NiPERA and guest edited by E. Garman. This section is made up of twelve articles that represent a technical review of metal mixture theory and research, syntheses of methods and results from the MMME project, technical basis and applications of bioavailability-based modeling approaches, and new metal mixture data sets. The issue was published in the April 2015 issue of ET&C 34(4).

Meyer JS, Farley KJ, Garman ER. 2015. Metal Mixtures Modeling Evaluation: 1. Background. Environmental Toxicology and Chemistry 34(4): 726-740.

Van Genderen E, Adams W, Dwyer R, Garman E, Gorsuch J, 2015. Modeling and Interpreting Biological Effects of Mixtures in the Environment- Introduction to the Metal Mixture Modeling Evaluation Project. Environmental Toxicology and Chemistry 34(4): 721-5.

 

Below are two reports on the rapid removal from the water column method development and supporting studies that illustrates how the T/DP-E may be combined with additional findings to support the weight of evidence evaluation for nickel removal from the water column.

University of Michigan Report on Nickel-Specific Research (February 2018)

Kent State University Report on Nickel-Specific Research (January 2018)